abstract：BACKGROUND/AIM:Despite recent introduction of several novel agents, limited data exist regarding parameters that help predict the progression of non-metastatic castration-resistant prostate cancer (nmCRPC). The objective of this study was to identify prognostic predictors in nmCRPC patients. PATIENTS AND METHODS:This ...

journal_title：Anticancer research

authors： Miyake H,Watanabe K,Matsushita Y,Watanabe H,Tamura K,Motoyama D,Ito T,Sugiyama T,Otsuka A

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:A gastrostomy feeding tube is one method for long-term feeding support in patients undergoing radio(chemo)therapy for head and neck cancer (HNC). The aim of this study was to analyze the safety of prophylactic gastrostomy tube placement and usage in HNSCC patients. PATIENTS AND METHODS:HNC patients undergoi...

journal_title：Anticancer research

authors： Sieron HL,Eberle F,Gress TM,Mahnken AH,Wiegand S

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND/AIM:Even though prostate cancer (PCa) has good prognosis, there is a discrepancy in the risk among ethnic groups, with high morbidity in African American men. Single nucleotide polymorphisms (SNPs) in interleukin 10 (IL-10) have been associated with inflammation and cancer risk. We investigated the associati...

journal_title：Anticancer research

authors： Abbas M,Mason T,Ibad A,Khraiwesh M,Apprey V,Kanaan Y,Wilson B,Dunston G,Ricks-Santi L,Brim H

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND/AIM:Pancreatic neuroendocrine tumors (pNETs) are rare pancreatic neoplasms, and therapeutic options for pNETs are limited. Metformin is an anti-hypoglycemic drug that appears to have anticancer effects. However, little is known about the effect of metformin on pNETs. In this study, we investigated the anti-p...

journal_title：Anticancer research

authors： Yamana H,Kato K,Kobara H,Fujihara S,Fujita K,Namima D,Fujita N,Kobayashi K,Kamada H,Morishita A,Tsutsui K,Iwama H,Masaki T

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND/AIM:Autophagy can be either tumor promotive or suppressive. We previously identified an autophagy-inducing activity in the 30-100 kDa fraction of areca-nut-extract (ANE 30-100K) and showed that several tumor cells subjected to chronic ANE 30-100K stimulation (CAS) exhibited higher resistance against stressed...

journal_title：Anticancer research

authors： Chiu CT,Liu SY,Yen CY,Liu BY,Sun ZY,Wu CY,Deng JL,Liu YC,Lin MH

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND/AIM:To clarify whether renal dysfunction affects the incidence of adverse events associated with oxaliplatin, the present study was designed to investigate the relationship between creatinine clearance (Ccr) and the incidence of oxaliplatin-related adverse events. PATIENTS AND METHODS:A total of 287 CRC pat...

journal_title：Anticancer research

authors： Watanabe D,Fujii H,Yamada Y,Iihara H,Ishihara T,Matsuhashi N,Takahashi T,Yoshida K,Suzuki A

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND/AIM:We evaluated the efficacy and safety of carbon-ion radiotherapy (CIRT) alone for Stage III non-small-cell lung cancer (NSCLC). PATIENTS AND METHODS:Data of 65 patients (median age=73 years) with Stage III NSCLC who underwent CIRT alone in the QST Hospital, Chiba, Japan, between 1997 and 2015 were retros...

journal_title：Anticancer research

authors： Anzai M,Yamamoto N,Hayashi K,Nakajima M,Nomoto A,Ogawa K,Tsuji H

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND/AIM:We evaluated the clinical implications of pre- and post-treatment hematological parameters as prognostic factors in patients with locally advanced cervical cancer (LACC) who received definitive concurrent chemoradiotherapy (CCRT). PATIENTS AND METHODS:We retrospectively analyzed 125 patients with LACC (...

journal_title：Anticancer research

authors： Lee HJ,Kim JM,Chin YJ,Chong GO,Park SH,Lee YH,Hong DG,Lee YS

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND/AIM:Many studies have shown an antiproliferative, anti-inflammatory, anti-angiogenetic, and apoptosis-inducing effect of Vitamin D. A vitamin D deficiency has been associated with an increased risk for different types of cancer. This study examined vitamin D 25(OH)D levels in gynaecological cancers in compar...

journal_title：Anticancer research

authors： Kolnsberg L,Riffelmann M,Friedrich M

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND/AIM:The aim of the present study was to determine the efficacy of trabectedin combined with FOLFIRI (irinotecan, leucovorin and 5-fluorouracil) on a colorectal cancer (CRC) patient-derived orthotopic xenograft (iPDOX) mouse model. MATERIALS AND METHODS:A CRC tumor from a patient previously established in nu...

journal_title：Anticancer research

authors： Zhu G,Zhao M,Han Q,Tan Y,Sun YU,Bouvet M,Clary B,Singh SR,Ye J,Hoffman RM

更新日期：2019-12-01 00:00:00

abstract：AIM:To evaluate the frequency of loss of mediator of DNA damage checkpoint protein 1 (MDC1) protein expression in endometrial cancer (EC) and to determine whether loss of MDC1 is associated with certain clinicopathological parameters. MATERIALS AND METHODS:MDC1 expression was examined in 426 samples of EC. The nuclear...

journal_title：Anticancer research

authors： Merentitis D,Nguyen BD,Samartzis EP,Noske A,Brandt S,Dedes KJ

更新日期：2019-12-01 00:00:00

abstract：AIM:The aim of this study was to investigate the effects of medium-chain triglycerides (MCTs) on chemically-induced hepatic carcinogenesis (HCC) in mice. MATERIALS AND METHODS:In a first set of experiments, mice were treated with diethylnitrosoamine intraperitoneally at two weeks of age. They were fed chow containing ...

journal_title：Anticancer research

authors： Wakana H,Kono H,Fukushima H,Nakata Y,Akazawa Y,Maruyama S,Hagio K,Fujii H,Ichikawa D

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND/AIM:Our original hypothesis was that the rectus sheath block (RSB) analgesia could enhance patient satisfaction and decrease pain following midline laparotomy. PATIENTS AND METHODS:Initially, 56 patients were randomized into four groups; control group (n=12), single-dose (n=16), repeated-dose (n=12) and con...

journal_title：Anticancer research

authors： Kuosmanen V,Ruottinen M,Rahkola D,Saimanen I,Kaaronen V,Selander T,Purdy M,Kokki H,Kokki M,Eskelinen M

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND/AIM:Typical carcinoids (TC) and atypical carcinoids (AC) are rare diseases. A paucity of randomized studies and disagreements among various guidelines makes the management challenging. PATIENTS AND METHODS:Using codes for TC (8240) and AC (8249) in the National Cancer Database (NCDB), all surgically resecte...

journal_title：Anticancer research

authors： Gosain R,Groman A,Yendamuri SS,Iyer R,Mukherjee S

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND/AIM:The objective of this phase I study was to determine the maximum-tolerated dose (MTD) and recommended dose (RD) of combination therapy with weekly nanoparticle albumin-bound paclitaxel (nab-paclitaxel) and cyclophosphamide (CPA) in metastatic breast cancer (MBC) patients. PATIENTS AND METHODS:Five patie...

journal_title：Anticancer research

authors： Ota D,Akatsuka S,Nishi T,Kato T,Takeuchi M,Tsuji M,Fukuuchi A

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND/AIM:Individualized proper chemotherapy using in vitro drug sensitivity testing has been proposed as a novel therapeutic modality and shown to have better efficacy than empiric chemotherapy. However, issues around establishing a patient-derived cell culture or xenograft, the timing of the testing obtained, an...

journal_title：Anticancer research

authors： Vinayanuwattikun C,Prakhongcheep O,Tungsukruthai S,Petsri K,Thirasastr P,Leelayuwatanakul N,Chanvorachote P

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:We hypothesized that ancestry-mediated methylated DNA changes may drive racial and ethnic disparity in prostate cancer (PCa). To test this hypothesis, we analyzed genetic ancestry and association with DNA methylation changes in PCa disparity. MATERIALS AND METHODS:Pyrosequencing and ancestry informative mar...

journal_title：Anticancer research

authors： Apprey V,Wang S,Tang W,Kittles RA,Southerland WM,Ittmann M,Kwabi-Addo B

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND/AIM:The presence of ascites in ovarian cancer patients is considered a negative prognostic factor. The underlying mechanisms are not clearly understood. MATERIALS AND METHODS:The amount of ascites was evaluated, preferably, using diffusion-weighted MRI at primary diagnosis in a retrospective cohort of 214 w...

journal_title：Anticancer research

authors： Coosemans AN,Baert T,D'Heygere V,Wouters R,DE Laet L,VAN Hoylandt A,Thirion G,Ceusters J,Laenen A,Vandecaveye V,Vergote I

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND/AIM:We have previously reported that alternate-day S-1 had comparable effects and milder adverse events than the respective consecutive-day regimen in head and neck cancer (HNC) patients. The aim of this study was to investigate the anticancer effects of both regimens and underlying mechanisms in vitro. MAT...

journal_title：Anticancer research

authors： Moro Y,Kogashiwa Y,Sakurai H,Takahashi R,Kimura T,Hirasaki M,Matsumoto Y,Sugasawa M,Kohno N

更新日期：2019-11-01 00:00:00

abstract：AIM:The aim of the study was to identify novel biomarkers that are vital for improving management of patients with gastric cancer (GC). MATERIALS AND METHODS:An RNA-sequencing analysis was conducted using gastric tissue from patients with metastatic GC. In vitro cell functions were evaluated by siRNA-mediated knockdow...

journal_title：Anticancer research

authors： Sawaki K,Kanda M,Umeda S,Miwa T,Tanaka C,Kobayashi D,Hayashi M,Yamada S,Nakayama G,Omae K,Koike M,Kodera Y

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND/AIM:Elderly cancer patients are more prevalent and require special attention. This study focused on the outcome of elderly (≥65 years) rectal cancer patients treated with tri-modality therapy. PATIENTS AND METHODS:A total of 105 patients receiving neoadjuvant radio-chemotherapy and resection for locally adv...

journal_title：Anticancer research

authors： Treder M,Janssen S,Schild SE,Rades D

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND/AIM:A minority of grade I meningiomas (MG1s) recur after surgical resection and their progression is associated with high grade transformation (HGT). This study aimed to characterize the clinicoradiological features of recurrent MGs (RMG) with HGT. PATIENTS AND METHODS:We identified 17 patients diagnosed wi...

journal_title：Anticancer research

authors： Yeon EK,Sung JY,DO SI,Park BJ,Kim EJ,Na K

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND/AIM:Radiotherapy (RT) with adjuvant hormone therapy (HT) improves prognosis in prostate cancer (PC) patients. Gonadotrophin-releasing hormone agonist (GnRHa) with luteinizing hormone-releasing hormone (LH-RH) analogues is the standard HT. High-dose antiandrogen therapy also improves survival in patients with...

journal_title：Anticancer research

authors： Buwenge M,Deodato F,Macchia G,Siepe G,Zhao X,Valicenti RK,Cilla S,Alitto AR,Ntreta M,Bisello S,Mantini G,Valentini V,Morganti AG,Cammelli S

更新日期：2019-11-01 00:00:00

abstract：BACKGROUND/AIM:The mechanism responsible for B-cell translocation gene 1 (BTG1) down-regulation in breast carcinoma remains unknown. We examined the BTG1 expression status in breast carcinoma cells and investigated the mechanism underlying the observed alterations. MATERIALS AND METHODS:Four breast carcinoma cell line...

journal_title：Anticancer research

authors： Woo HY,DO SI,Kim SH,Song SY,Kim HS

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND/AIM:Multidrug resistance (MDR) is often associated with overexpression of P-glycoprotein (ABCB1) in cancer cells. Apatinib is a novel Vascular endothelial growth factor receptor-TKI (VEGFR-TKI) which inhibits the function of ABCB1 in certain cancers. This study aimed to investigate the effect of apatinib on ...

journal_title：Anticancer research

authors： Zhang Q,Song Y,Cheng X,Xu Z,Matthew OA,Wang J,Sun Z,Zhang X

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND/AIM:Tyrosine kinase inhibitors are important in the treatment of metastatic renal cell cancer (mRCC). The aim of the study was to evaluate the costs and effects of sunitinib in mRCC. PATIENTS AND METHODS:A total of 81 mRCC patients who received first-line sunitinib therapy between 2010 and 2014 were recruit...

journal_title：Anticancer research

authors： Vuorinen RL,Paunu N,Turpeenniemi-Hujanen T,Reunamo T,Jekunen A,Kataja V,Sintonen H,Purmonen T,Kellokumpu-Lehtinen PL

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND/AIM:Pelvic exenteration is a radical procedure for certain advanced or recurrent gynaecological cancers, performed with curative or palliative intent. Its validity has evolved as operative mortality and morbidity have improved. This surgery was evaluated to determine the validity of these claims. PATIENTS A...

journal_title：Anticancer research

authors： Soeda S,Furukawa S,Sato T,Ueda M,Kamo N,Endo Y,Kojima M,Nomura S,Kataoka M,Fujita S,Endo H,Takahashi T,Watanabe T,Yamada H,Fujimori K

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND/AIM:Anthracyclines, such as doxorubicin, though widely used in anticancer therapy, they are associated with cardiotoxic side-effects. The aim of this trial was to investigate long-term follow-up cardiotoxicity findings in patients treated with doxorubicin and concomitant metoprolol or enalapril 10 years earl...

journal_title：Anticancer research

authors： Georgakopoulos P,Kyriakidis M,Perpinia A,Karavidas A,Zimeras S,Mamalis N,Kouvela M,Charpidou A

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND/AIM:To investigate the impact of inguinal lymph node dissection (ILND) following neoadjuvant chemoradiotherapy (NACRT) for rectal cancer patients with ILN metastasis. PATIENTS AND METHODS:Forty-three patients with rectal cancer underwent NACRT followed by curative surgery between January 2005 and December 2...

journal_title：Anticancer research

authors： Ueta K,Matsuda T,Yamashita K,Hasegawa H,Mukohyama J,Yamamoto M,Matsuda Y,Kanaji S,Oshikiri T,Nakamura T,Suzuki S,Kakeji Y

更新日期：2019-10-01 00:00:00

abstract：:In the clinical setting, administration of high daily or bolus doses of vitamin D is often solely based on 25-hydroxyvitamin D [25(OH)D] testing. This review summarizes the evidence of the effect of vitamin D on cardiovascular disease (CVD). Meta-analyses of randomized controlled trials (RCTs) have demonstrated that C...

journal_title：Anticancer research

authors： Zittermann A,Pilz S

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND/AIM:Dynamics of circulating tumor cells (CTCs) after molecular targeting therapy remain unclear. MATERIALS AND METHODS:We examined changes in CTC numbers and morphology early after targeting therapy in EGFR-mutated PC-9 human lung cancer and HER2-gene amplified GLM-1 gastric cancer mouse CTC models using a ...

journal_title：Anticancer research

authors： Ito A,Nakanishi H,Yoshimura M,Ito S,Sakao Y,Kodera Y,Yatabe Y,Kaneda N

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND/AIM:The aim of this study was to investigate the effects of the macrophage colony-stimulating factor (M-CSF) receptor antagonist on hepatic carcinogenesis in mice. MATERIALS AND METHODS:Mice were injected with diethylnitrosamine (DEN) and treated with M-CSF receptor antagonist GW2580 (GW) or a saline vehicl...

journal_title：Anticancer research

authors： Akazawa Y,Kono H,Hara M,Furuya S,Nakata Y,Wakana H,Fukushima H,Sun C,Fujii H,Ichikawa D

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND/AIM:We investigated the effect of aspirin on colorectal cancer (CRC) risk among subgroups of women with and without risk factors for CRC. PATIENTS AND METHODS:Using data from the Women's Health Initiative, we estimated hazard ratios for CRC in association with aspirin use, with stratifications by cardiovasc...

journal_title：Anticancer research

authors： Seaton ME,Peters U,Johnson KC,Kooperberg C,Bafford A,Zubair N

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND/AIM:Insulin-like growth factor II mRNA-binding protein 3 (IMP3) plays an important role in the adhesion, invasion, and metastasis of tumor cells. Although emerging evidence suggests that IMP3 promotes tumor progression in several malignancies, the expression of IMP3 and its prognostic implication in adenocar...

journal_title：Anticancer research

authors： Kim HG,Park MS,Sung JY,Kim YW,Kim HS,Na K

更新日期：2019-09-01 00:00:00

abstract：AIM:The purpose of this study was to identify patient-, facility-, disease-, and treatment-specific characteristics that increase mortality in patients with upper limb osteosarcoma. PATIENTS AND METHODS:The National Cancer Data Base (NCDB) was queried for bone cancer. With Cox regression, the demographic, facility, tu...

journal_title：Anticancer research

authors： Restrepo DJ,Huayllani MT,Boczar D,Sisti A,Spaulding AC,Carter RE,Moran SL,Parker AS,Perdikis G,Forte AJ

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND/AIM:We evaluated the clinical impact of FOLFOXIRI regimen aiming for conversion surgery in patients with unresectable multiple colorectal liver metastasis (CRLM). PATIENTS AND METHODS:A total of 42 patients with unresectable multiple CRLM who received chemotherapy with molecular agents were included in the ...

journal_title：Anticancer research

authors： Morine Y,Ikemoto T,Iwahashi S,Saito YU,Yamada S,Takasu C,Higashijima J,Imura S,Shimada M

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND/AIM:The aim of this study was to analyze the pretreatment cytokeratin serum levels in head and neck squamous cell carcinoma (HNSCC) by three assays in relation to selected clinicopathological characteristics in an effort to find diagnostic/prognostic biomarkers for HNSCC and determine the best assay. PATIEN...

journal_title：Anticancer research

authors： Kalfert D,Ludvik J,Kucera R,Topolcan O,Celakovsky P,Pesta M,Kholova I,Plzak J,Ludvikova M

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Different phenomena can result in enlargement of mental foramen and mandibular canal. At the foreground of diagnosis is the assessment of the biological properties of the tissue which causes such detailed lesions of the skeleton. CASE REPORT:This report describes a palpable mass at the site of the mental fo...

journal_title：Anticancer research

authors： Friedrich RE,Matschke J,Wilczak W

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND/AIM:ANRIL is a long noncoding RNA located on INK4 locus, which encodes p15 and p16 that cause G1 phase arrest in the cell cycle. ANRIL positively regulates proliferation of several kinds of cancer cells such as lung and gastric cancers. This study, examined the effect of ANRIL in head and neck squamous cell ...

journal_title：Anticancer research

authors： Matsunaga N,Wakasaki T,Yasumatsu R,Kotake Y

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND/AIM:Signaling regulation of myeloid zinc finger 1 (MZF1) has been implicated in the progression of many human malignancies; however, the mechanistic action of MZF1 in triple-negative breast cancer (TNBC) progression remains elusive. In this study, the aim was to investigate the molecular mechanisms of MZF1 a...

journal_title：Anticancer research

authors： Yue CH,Liu JY,Chi CS,Hu CW,Tan KT,Huang FM,Pan YR,Lin KI,Lee CJ

更新日期：2019-08-01 00:00:00